Melanotan I
$65.99
This material is supplied solely as a laboratory research article. Buyer is responsible for ensuring lawful purchase, handling, storage, and use. We do not provide administration or therapeutic guidance.
Quality Certificates
Independent third-party lab analysis (CoA) - from our own in-house brand.
📦Also available in a stack · save up to $194.95
Glow - Advancedsave $194.95View the stack →Melanotan I - Synthetic Alpha-MSH Analog Peptide, Research Reference Material
FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.


Analytical Identity
| Common name | Melanotan I |
|---|---|
| Amino-acid sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| CAS Number | 75921-69-6 |
| PubChem CID | 16132139 |
| InChIKey | UAHFGYDRQSXQEB-PWPYQVNISA-N |
| SMILES | CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C |
| Molecular formula | C78H111N21O19 |
|---|---|
| Molecular weight | 1646.85 g/mol |
| Monoisotopic mass | 1645.8365 Da |
| Appearance | White to off-white lyophilized powder |
| Physical form | Lyophilized powder |
| Purity | Not less than 98% by HPLC (see lot-specific Certificate of Analysis) |
|---|---|
| Source | Synthetic |
| Catalog / SKU | Melanotan-I |
Melanotan I is supplied as a laboratory research reference material for in-vitro and laboratory research use only. It is a synthetic 13-residue linear peptide analog of alpha-melanocyte stimulating hormone (alpha-MSH), assembled with N-terminal acetylation and a C-terminal primary amide to give the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. Two structural modifications distinguish this analog from the parent tridecapeptide: substitution of Met-4 with norleucine (Nle) and inversion of Phe-7 to the D-enantiomer, both of which are widely documented in the peptide chemistry literature as means of increasing conformational and oxidative stability of the reference standard.
The material is characterized by the empirical molecular formula C78H111N21O19, an average molecular weight of 1646.85 g/mol, and a monoisotopic mass of 1645.8365 Da, consistent with CAS registry number 75921-69-6 and PubChem CID 16132139. Structural identity is further indexed by InChIKey UAHFGYDRQSXQEB-PWPYQVNISA-N and the isomeric SMILES string CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C, which together provide unambiguous machine-readable descriptors for cheminformatics workflows, spectral library matching, and internal chain-of-custody tracking.
Melanotan I is provided as a white to off-white lyophilized powder of synthetic origin, with purity not less than 98% as determined by reversed-phase HPLC (see lot-specific Certificate of Analysis for the exact assay value, related-substance profile, water content, counter-ion content, and mass-spectrometric confirmation of the target molecular ion). The lyophilized format supports reconstitution in a range of laboratory solvent systems typically used by analytical chemists working with acidic, basic, and neutral residues (Glu, Arg, Lys, His) alongside aromatic Tyr and Trp chromophores that lend themselves to UV detection near 220 and 280 nm.
Published scientific literature has examined Melanotan I in preclinical research, and the peptide is frequently cited as a reference standard in structure-activity investigations of melanocortin receptor ligands and in method development for peptide identity, potency, and stability assays. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance.
This material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. Identity and purity are documented on the lot-specific Certificate of Analysis, available on request, to support qualification of Melanotan I within the receiving laboratory's quality system.
Physical format
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. A research reference material - not a finished product and not a delivery device. Net contents per unit are shown in the product options.
Certificate of Analysis
| Issuing laboratory | Analiza Białek |
|---|---|
| Analyte | Melanotan I |
| CAS Number | 75921-69-6 |
| Lot / Batch | K12PP |
| Appearance | White to off-white lyophilized powder |
| Purity (HPLC) | 99% |
| Identity | Confirmed by HPLC and mass spectrometry |
Lot-specific COA available — contact [email protected] with your lot number.
Storage & handling
Store the sealed lyophilized powder at -20 C, protected from light and moisture. After reconstitution for laboratory use, keep cold and use promptly. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.
Scientific references
The following are independent, peer-reviewed publications provided for reference. They describe third-party research and are not representations by POWER BIOTECH LLC regarding this product.
- Afamelanotide for prevention of phototoxicity in patients with erythropoietic protoporphyria — https://pubmed.ncbi.nlm.nih.gov/26157440/
- Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo — https://pmc.ncbi.nlm.nih.gov/articles/PMC4334465/
- Photoprotection by melanocortin 1 receptor agonists — https://pubmed.ncbi.nlm.nih.gov/19796020/
- The melanocortin-1 receptor: red hair and beyond — https://pmc.ncbi.nlm.nih.gov/articles/PMC6151224/
- Melanocortin 1 receptor signaling and skin pigmentation — https://pubmed.ncbi.nlm.nih.gov/18435749/
Eligibility & terms of sale
This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.
FAQ
What is the purity and how is it verified?
Not less than 98% by HPLC; see the Certificate of Analysis for the lot-specific result.
What form does it ship in?
A lyophilized powder in a sealed vial.
Can you advise on dosing, reconstitution, or administration?
No. We provide batch documentation, storage, and handling information only; we do not provide dosing, reconstitution, administration, or therapeutic guidance.
Is lot-specific documentation available?
Yes - contact [email protected] with your lot number for the Certificate of Analysis.
Related reference materials
Sold by POWER BIOTECH LLC, Casper, WY 82609, United States · [email protected]. FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.
