PEG-MGF

PEG-MGF (Pegylated Mechano Growth Factor Analog) is supplied as a laboratory research reference material intended exclusively for in-vitro and laboratory research use. The construct is built around a 24-residue MGF core peptide with the primary sequence YQPPSTNKNTKSQRRKGSTFEERK (Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys), which corresponds to the alternatively spliced C-terminal E-domain segment characteristic of the mechano growth factor isoform. The core peptide has the molecular formula C121H200N42O39 and a calculated monoisotopic core mass of approximately 2867 g/mol, with the pegylated conjugate typically presenting an apparent mass in the ~7-12 kDa range depending on the polyethylene glycol chain length and coupling chemistry used during synthesis.

Structurally, the MGF core is a highly basic, arginine- and lysine-rich sequence (four Lys, three Arg, two Glu) giving it a strong net positive charge at neutral pH and a theoretical pI in the alkaline range. This charge profile, together with the multiple Ser/Thr hydroxyl side chains and two adjacent proline residues near the N-terminus, informs analytical handling: reversed-phase HPLC on C18 with a TFA/acetonitrile gradient is generally suitable for identity and purity assessment, while ESI mass spectrometry can be used to confirm the intact conjugate mass envelope characteristic of PEG polydispersity. The pegylation moiety, appended to the MGF core, is intended in research settings to serve as a hydrodynamic radius modifier and proteolysis-resistance handle relative to the unmodified MGF peptide - a comparison frequently referenced in the peer-reviewed literature examining PEG-MGF in preclinical, non-clinical research contexts.

The material is offered as a synthetic, white to off-white lyophilized powder with purity not less than 98% by HPLC, as documented on the lot-specific Certificate of Analysis available on request. Each lot is characterized for identity, chromatographic purity and net peptide content, providing a defined reference standard suitable for method development, analytical qualification, comparability studies and structure-activity investigations at the bench. For laboratory reconstitution, PEG-MGF is typically handled in the same manner as other cationic peptide reference materials; the pegylated portion generally enhances aqueous solubility of the conjugate relative to the core sequence alone. Store lyophilized material desiccated and protected from light per the Certificate of Analysis to preserve integrity between analytical uses.

PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding PEG-MGF and provides no administration or dosing guidance of any kind. This PEG-MGF reference material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. It is sold and shipped solely as a chemical reference item for qualified researchers conducting in-vitro and laboratory-scale investigations.

Supplied as a lyophilized (freeze-dried) powder in a sealed vial. A research reference material - not a finished product and not a delivery device. Net contents per unit are shown in the product options.

Store the sealed lyophilized powder at -20 C, protected from light and moisture. After reconstitution for laboratory use, keep cold and use promptly. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.

This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.