ARA-290 (Cibinetide)
$54.99
This material is supplied solely as a laboratory research article. Buyer is responsible for ensuring lawful purchase, handling, storage, and use. We do not provide administration or therapeutic guidance.
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Analytical Identity
| Common name | ARA-290 |
|---|---|
| Amino-acid sequence | PHBSPGDKQTNS (Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser) |
| Sequence (3-letter) | Ser-Pro-Gly-Asp-Lys-Gln-Thr-Asn-Ser |
| Residues | 9 |
| CAS Number | 1208243-50-8 |
| Molecular formula | C49H72N14O18 |
|---|---|
| Molecular weight | ~1257 g/mol |
| Appearance | White to off-white lyophilized powder |
| Physical form | Lyophilized powder |
| Purity | Not less than 98% by HPLC (see lot-specific Certificate of Analysis) |
|---|---|
| Source | Synthetic |
| Catalog / SKU | ARA-290 |
ARA-290 (CAS 1208243-50-8) is offered by PEPTIDE.Power as a synthetic laboratory research reference material intended strictly for in-vitro and laboratory research use. As an 11-residue linear peptide derived from the aqueous-exposed helix B region of erythropoietin, ARA-290 belongs to the class of non-erythropoietic EPO-mimetic sequences frequently used as reference standards in peptide characterization workflows.
The material is defined by the molecular formula C49H72N14O18 and a monoisotopic/average molecular weight of approximately 1257 g/mol, providing a distinctive mass signature for LC-MS and MALDI-TOF confirmation. Its declared amino-acid sequence is PHBSPGDKQTNS, corresponding to Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser, and the item is cataloged under SKU ARA-290. The N-terminal pyroglutamate (Pyr-Glu) cap is a notable structural feature that eliminates a free alpha-amino group at that position, which analysts should account for when planning Edman degradation, N-terminal labeling, or ion-pair reversed-phase HPLC method development. Multiple acidic (Glu), basic (Arg, Lys), and polar hydroxyl-bearing (Ser, Thr, Asn) residues contribute to a mixed hydrophilic character relevant to solubility screening and buffer compatibility studies.
Physically, ARA-290 is supplied as a white to off-white lyophilized powder produced by solid-phase peptide synthesis, with purity specified at not less than 98% by HPLC and confirmed on a lot-specific Certificate of Analysis available on request. The CoA typically documents identity by mass spectrometry, purity by reversed-phase HPLC, appearance, and related quality attributes, supporting traceability for comparative reference work, assay calibration, method qualification, and analytical benchmarking against in-house or third-party ARA-290 lots.
Published scientific literature has examined ARA-290 in preclinical research contexts, and this listing is provided solely to describe the compound's chemistry and analytical identity. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding ARA-290 and provides no administration, formulation, or dosing guidance of any kind.
This material is not a drug, dietary supplement, cosmetic, or food. It is not intended or suitable for human or veterinary use, injection, ingestion, topical application, or any in-vivo administration, and should be handled exclusively by qualified personnel within an appropriately equipped research laboratory under applicable institutional and regulatory guidelines.
Physical format
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. A research reference material - not a finished product and not a delivery device. Net contents per unit are shown in the product options.
Certificate of Analysis
| Analyte | ARA-290 |
|---|---|
| CAS Number | 1208243-50-8 |
| Appearance | White to off-white lyophilized powder |
| Identity | Confirmed by HPLC and mass spectrometry |
Lot-specific COA available — contact [email protected] with your lot number.
Storage & handling
Store the sealed lyophilized powder at -20 C, protected from light and moisture. After reconstitution for laboratory use, keep cold and use promptly. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.
Scientific references
The following are independent, peer-reviewed publications provided for reference. They describe third-party research and are not representations by POWER BIOTECH LLC regarding this product.
- ARA 290, a specific agonist of erythropoietin/CD131 heteroreceptor, improves circulating endothelial progenitors' angiogenic potential and homing ability — https://pubmed.ncbi.nlm.nih.gov/27045073/
- ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density — https://pmc.ncbi.nlm.nih.gov/articles/PMC4459411/
- Effect of the innate immune modulator ARA 290 on inflammation-related biomarkers in patients with sarcoidosis: A phase 2a study — https://pubmed.ncbi.nlm.nih.gov/27922228/
- A nonhematopoietic erythropoietin analogue, ARA 290, inhibits macrophage activation and prevents damage to transplanted islets — https://pmc.ncbi.nlm.nih.gov/articles/PMC3146349/
- ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury — https://pubmed.ncbi.nlm.nih.gov/24300843/
- Cibinetide improves quality of life in patients with sarcoidosis-associated small fiber neuropathy — https://pmc.ncbi.nlm.nih.gov/articles/PMC4747246/
Eligibility & terms of sale
This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.
FAQ
What is the purity and how is it verified?
Not less than 98% by HPLC; see the Certificate of Analysis for the lot-specific result.
What form does it ship in?
A lyophilized powder in a sealed vial.
Can you advise on dosing, reconstitution, or administration?
No. We provide batch documentation, storage, and handling information only; we do not provide dosing, reconstitution, administration, or therapeutic guidance.
Is lot-specific documentation available?
Yes - contact [email protected] with your lot number for the Certificate of Analysis.
Related reference materials
Sold by POWER BIOTECH LLC, Casper, WY 82609, United States · [email protected]. FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.
