Melanotan II
$65.99
This material is supplied solely as a laboratory research article. Buyer is responsible for ensuring lawful purchase, handling, storage, and use. We do not provide administration or therapeutic guidance.
Quality Certificates
Independent third-party lab analysis (CoA) - from our own in-house brand.
Melanotan II - Synthetic Alpha-MSH Analog Peptide, Research Reference Material
FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.


Analytical Identity
| Common name | Melanotan II |
|---|---|
| Amino-acid sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| CAS Number | 121062-08-6 |
| PubChem CID | 92432 |
| InChIKey | JDKLPDJLXHXHNV-MFVUMRCOSA-N |
| SMILES | CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C |
| Molecular formula | C50H69N15O9 |
|---|---|
| Molecular weight | 1024.18 g/mol |
| Monoisotopic mass | 1023.5403 Da |
| Appearance | White to off-white lyophilized powder |
| Physical form | Lyophilized powder |
| Purity | Not less than 98% by HPLC (see lot-specific Certificate of Analysis) |
|---|---|
| Source | Synthetic |
| Catalog / SKU | Melanotan-II |
Melanotan II is supplied as a laboratory research reference material intended solely for in-vitro and laboratory research use. This synthetic cyclic heptapeptide is defined by the amino-acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, in which an N-terminal acetyl cap and a C-terminal primary amide flank a lactam bridge formed between the side-chain carboxyl of Asp and the epsilon-amine of Lys. The Nle (norleucine) substitution at position 4 and the D-Phe stereoinversion at position 7 are hallmark structural modifications relative to the parent alpha-MSH core sequence His-Phe-Arg-Trp, and are of interest as reference features in comparative peptide chemistry studies.
The compound is registered under CAS 121062-08-6 and PubChem CID 92432, with molecular formula C50H69N15O9, average molecular weight 1024.18 g/mol, and monoisotopic mass 1023.5403 Da. The canonical SMILES string CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C and InChIKey JDKLPDJLXHXHNV-MFVUMRCOSA-N provide unambiguous identifiers for cheminformatics workflows, database cross-referencing, and analytical method development involving Melanotan II.
Physically, Melanotan-II (catalog SKU: Melanotan-II) is presented as a white to off-white lyophilized powder of synthetic origin. Purity is specified as not less than 98% by HPLC, with lot-specific chromatographic, mass-spectrometric, and appearance data captured on the Certificate of Analysis available on request. The 27-atom macrocycle and the presence of aromatic (His, D-Phe, Trp) and basic (Arg) side chains give the molecule a distinctive UV profile useful in reversed-phase HPLC detection, while the monoisotopic mass of 1023.5403 Da supports confirmation by high-resolution ESI-MS.
Published scientific literature has examined Melanotan II in preclinical research contexts, and the material is offered here strictly to support qualified laboratory investigators requiring a well-characterized analytical reference. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding Melanotan II and provides no administration or dosing guidance of any kind. This material is not a drug, supplement, cosmetic, or food, and is not intended for human or veterinary use, injection, or ingestion. Identity, purity, and lot-specific characterization data are documented on the Certificate of Analysis, available on request.
Physical format
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. A research reference material - not a finished product and not a delivery device. Net contents per unit are shown in the product options.
Certificate of Analysis
| Issuing laboratory | Analiza Białek |
|---|---|
| Analyte | Melanotan II |
| CAS Number | 121062-08-6 |
| Lot / Batch | K12PP |
| Appearance | White to off-white lyophilized powder |
| Purity (HPLC) | 99% |
| Identity | Confirmed by HPLC and mass spectrometry |
Lot-specific COA available — contact [email protected] with your lot number.
Storage & handling
Store the sealed lyophilized powder at -20 C, protected from light and moisture. After reconstitution for laboratory use, keep cold and use promptly. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.
Scientific references
The following are independent, peer-reviewed publications provided for reference. They describe third-party research and are not representations by POWER BIOTECH LLC regarding this product.
- Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study — https://pubmed.ncbi.nlm.nih.gov/8637402/
- Melanotan II user experience: a qualitative study of online discussion — https://pubmed.ncbi.nlm.nih.gov/34464955/
- Melanotan II injection resulting in systemic toxicity and rhabdomyolysis — https://pubmed.ncbi.nlm.nih.gov/23121206/
- Melanotan II: a possible cause of renal infarction: review of the literature and case report — https://pmc.ncbi.nlm.nih.gov/articles/PMC7148395/
- Evidence that melanocortin receptor agonist melanotan-II synergistically augments the ability of naltrexone to blunt binge-like ethanol intake in male C57BL/6J mice — https://pmc.ncbi.nlm.nih.gov/articles/PMC4515169/
- Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide — https://pubmed.ncbi.nlm.nih.gov/7983590/
Eligibility & terms of sale
This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.
FAQ
What is the purity and how is it verified?
Not less than 98% by HPLC; see the Certificate of Analysis for the lot-specific result.
What form does it ship in?
A lyophilized powder in a sealed vial.
Can you advise on dosing, reconstitution, or administration?
No. We provide batch documentation, storage, and handling information only; we do not provide dosing, reconstitution, administration, or therapeutic guidance.
Is lot-specific documentation available?
Yes - contact [email protected] with your lot number for the Certificate of Analysis.
Related reference materials
Sold by POWER BIOTECH LLC, Casper, WY 82609, United States · [email protected]. FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.
