Klotho
This material is supplied solely as a laboratory research article. Buyer is responsible for ensuring lawful purchase, handling, storage, and use. We do not provide administration or therapeutic guidance.
Klotho - Recombinant Protein Reference, Research Reference Material
Analytical Identity
| Common name | Klotho |
|---|---|
| Amino-acid sequence | N/A |
| Residues | 1012 (full-length precursor, UniProt Q9UEF7) |
| CAS Number | N/A |
| PubChem CID | N/A |
| Molecular formula | N/A |
|---|---|
| Molecular weight | 116181 Da (calculated, unglycosylated, full-length precursor; UniProt Q9UEF7) |
| Appearance | See lot-specific Certificate of Analysis |
| Physical form | 1 mL pen |
| Purity | See lot-specific Certificate of Analysis |
|---|---|
| Source | Recombinant research protein |
| Catalog / SKU | KLOTHO |
| C-terminal albumin-binding tail | GGSGGSGGSGGRLIEDICLPRWGCLWEDD |
|---|---|
| Strength | 20 mcg per 1 mL pen |
| UniProt | Q9UEF7 |
Klotho is supplied as a laboratory research reference material, a full-length alpha-Klotho protein construct provided as a 1 mL pen containing 20 mcg per 1 mL pen. It is offered as an identity-defined reference item for in vitro characterization work by qualified researchers and is not formulated as a drug, supplement, cosmetic or food.
The construct corresponds to the human Klotho sequence catalogued under UniProt Q9UEF7 (KLOTH_HUMAN), a 1012-residue single-pass membrane protein. The UniProt-derived domain layout comprises a signal peptide spanning residues 1 to 33, a large extracellular region from residues 34 to 981 that contains two glycosyl hydrolase-1 type domains (KL1 at 57 to 506 and KL2 at 515 to 953), a transmembrane segment from residues 982 to 1002 and a short cytoplasmic region from residues 1003 to 1012. The calculated average molecular weight of the unglycosylated full-length precursor is 116181 Da. The material carries a C-terminal albumin-binding tail appended via a short glycine-serine linker, as described by Dennis and colleagues in 2002. No molecular formula, CAS number or PubChem CID is stated for this construct.
Each pen is accompanied by a lot-specific Certificate of Analysis describing the identity attributes recorded for that lot.
Published research literature on Klotho covers mouse genetics and its role as an FGF23 co-receptor, and is referenced here only as scientific context. PEPTIDE.Power makes no therapeutic, diagnostic or efficacy claims and provides no administration guidance; this material is not a drug, supplement, cosmetic or food, is not for human or veterinary use, injection or ingestion, and is intended for qualified researchers only.
Physical format
Supplied as a 1 mL pen containing 20 mcg of research reference material. A research reference material - not a finished product. Net contents per unit are shown in the product options.
Certificate of Analysis
| Analyte | Klotho |
|---|---|
| Strength | 20 mcg per 1 mL pen |
| Appearance | See lot-specific Certificate of Analysis |
Lot-specific COA available — contact [email protected] with your lot number.
Storage & handling
Store as directed on the label and in the lot documentation. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.
Scientific references
The following are independent, peer-reviewed publications provided for reference. They describe third-party research and are not representations by POWER BIOTECH LLC regarding this product.
- Kuro-o M, Matsumura Y, Aizawa H, et al. Nature 1997;390(6655):45-51 — https://pubmed.ncbi.nlm.nih.gov/9363890/
- Kurosu H, Yamamoto M, Clark JD, et al. Science 2005;309(5742):1829-1833 — https://pubmed.ncbi.nlm.nih.gov/16123266/
- Klotho converts canonical FGF receptor into a specific receptor for FGF23. — https://pubmed.ncbi.nlm.nih.gov/17086194/
- alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. — https://pubmed.ncbi.nlm.nih.gov/29342138/
Eligibility & terms of sale
This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.
FAQ
What is the purity and how is it verified?
See the lot-specific Certificate of Analysis for the result.
What form does it ship in?
A 1 mL pen containing 20 mcg of research reference material.
Can you advise on dosing, reconstitution, or administration?
No. We provide batch documentation, storage, and handling information only; we do not provide dosing, reconstitution, administration, or therapeutic guidance.
Is lot-specific documentation available?
Yes - contact [email protected] with your lot number for the Certificate of Analysis.
Related reference materials
Sold by POWER BIOTECH LLC, Casper, WY 82609, United States · [email protected]. FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.
