GHK-Cu

Copper Tripeptide-1 (GHK-Cu, CAS 89030-95-5) is a naturally occurring copper-binding tripeptide - glycyl-L-histidyl-L-lysine chelated to a divalent copper ion (Cu2+) - first identified in human plasma, where its concentration has been reported to decline with age, and later characterized in saliva and other biological fluids. The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions. This tight square-planar coordination geometry gives Copper Tripeptide-1 its characteristic d-d electronic absorption band and the distinctive blue-to-teal color of the isolated lyophilized powder. With a molecular formula of C14H24CuN6O4, a molecular weight of approximately 403.9 g/mol, and a monoisotopic mass of 402.1077 Da, GHK-Cu has become one of the most widely used peptide actives in modern cosmetic skincare, and is supplied here as a high-purity (>=98% by HPLC) synthetic, non-animal-derived raw material produced by solid-phase peptide synthesis for incorporation into topical formulations.

Formulators value Copper Tripeptide-1 for its contribution to the overall appearance of the skin. In leave-on and rinse-off cosmetic products, GHK-Cu is associated with the look of firmness and smoothness, a more even-looking tone and texture, a refined-looking surface, and the reduced visible appearance of fine lines and photo-aged features. It pairs well with other cosmetic actives - such as niacinamide, panthenol, hyaluronic acid, glycerin, beta-glucan, and stabilized antioxidants - in serums, essences, moisturizers, masks, and eye-area formulations, and can be worked into both aqueous and anhydrous systems when the formulation pH and ionic environment are properly controlled. Typical use levels in finished cosmetics fall in the low parts-per-thousand range, with formulators titrating to their desired sensory and color profile; even at modest concentrations the intrinsic blue-teal hue of the copper complex will tint the finished product, which should be accounted for in the color and packaging strategy.

Because the activity of this ingredient depends on the integrity of the copper-peptide coordination sphere, Copper Tripeptide-1 is typically introduced in the cool-down phase below roughly 40 degrees C to minimize thermal stress and oxidative loss. It should be kept away from strong chelators (such as high levels of EDTA and related sequestrants), reducing sugars, thiol-bearing actives, and high concentrations of direct acids (for example ascorbic acid or alpha-hydroxy acids at low pH), all of which can compete for the copper center or disrupt the peptide-metal bond and shift the characteristic blue color toward brown or colorless degradation products. A mildly acidic to near-neutral pH window is generally preferred, and compatibility trials with the specific preservative system, chelator, and surfactant package are recommended. The lyophilized powder should be stored cold, tightly closed, and protected from light and humidity; reconstituted stock solutions in cosmetic-grade water are best prepared fresh and used promptly.

For analytical and regulatory reference, Copper Tripeptide-1 is described by the SMILES string C1=C(NC=N1)CC(C(=O)NC(CCCCN)C(=O)[O-])NC(=O)CN.[Cu+2] and the InChIKey NZWIFMYRRCMYMN-ACMTZBLWSA-M, and each lot ships under the catalog reference GHK-Cu. Identity and purity of every batch - including HPLC purity, appearance, and relevant physicochemical parameters - are documented on the lot-specific Certificate of Analysis, available on request to support formulators' own specification and QC programs.

This product is a cosmetic ingredient, intended to be formulated into finished topical cosmetic products by qualified formulators. It is supplied for external topical cosmetic use in formulation only - not for injection, ingestion, or any medical application. The formulator or manufacturer is solely responsible for the safety assessment, stability testing, preservation, compatibility, labeling, and regulatory compliance of any finished cosmetic product made with Copper Tripeptide-1 (GHK-Cu).

Supplied as a lyophilized (freeze-dried) cosmetic-grade powder in a sealed container. Net contents per unit are shown in the product options. A raw cosmetic ingredient — not a finished consumer product and not a delivery device.

Store the sealed lyophilized powder at −20 °C, protected from light and moisture. Once dissolved into an aqueous phase, use promptly within a formulation. Handle per good manufacturing practice for cosmetic ingredients; a Safety Data Sheet (SDS) is available on request.

This cosmetic raw material is sold to formulators, cosmetic manufacturers, and businesses for use as a cosmetic ingredient. It is not a finished cosmetic, drug, or supplement and is not for injection, ingestion, or any internal use. By purchasing, you confirm you are 21 or older and that you will use this material only as a cosmetic raw material in compliance with all applicable laws.