Semax
$74.99
This material is supplied solely as a laboratory research article. Buyer is responsible for ensuring lawful purchase, handling, storage, and use. We do not provide administration or therapeutic guidance.
Quality Certificates
Independent third-party lab analysis (CoA) - from our own in-house brand.
📦Available in 2 stacks · save up to $114.95
Brain - Startsave $34.98View the stack →Brain - Advancedsave $114.95View the stack →Semax - Synthetic ACTH-Derived Heptapeptide, Research Reference Material
FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.


Analytical Identity
| Common name | Semax |
|---|---|
| Amino-acid sequence | MEHFPGP |
| Sequence (3-letter) | Met-Glu-His-Phe-Pro-Gly-Pro |
| Residues | 7 |
| CAS Number | 80714-61-0 |
| PubChem CID | 9811102 |
| InChIKey | AFEHBIGDWIGTEH-AQRCPPRCSA-N |
| SMILES | CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)NCC(=O)N4CCCC4C(=O)O)N |
| Molecular formula | C37H51N9O10S |
|---|---|
| Molecular weight | 813.9 g/mol |
| Monoisotopic mass | 813.3480 Da |
| Appearance | White to off-white lyophilized powder |
| Physical form | Lyophilized powder |
| Purity | Not less than 98% by HPLC (see lot-specific Certificate of Analysis) |
|---|---|
| Source | Synthetic |
| Catalog / SKU | Semax |
Semax is supplied as a laboratory research reference material intended strictly for in-vitro and laboratory research use only. This synthetic heptapeptide is a structural analog derived from a fragment of adrenocorticotropic hormone (ACTH 4-10), extended at the C-terminus with a Pro-Gly-Pro tripeptide motif that alters its physicochemical profile relative to the parent ACTH sequence. The linear seven-residue sequence is MEHFPGP (Met-Glu-His-Phe-Pro-Gly-Pro), incorporating a sulfur-containing methionine at the N-terminus, an acidic glutamate, an imidazole-bearing histidine, an aromatic phenylalanine, and two proline residues flanking a central glycine.
The Semax reference material is characterized by the molecular formula C37H51N9O10S, an average molecular weight of 813.9 g/mol, and a monoisotopic mass of 813.3480 Da, corresponding to CAS 80714-61-0 and PubChem CID 9811102. Stereochemistry and connectivity are captured by InChIKey AFEHBIGDWIGTEH-AQRCPPRCSA-N and the canonical SMILES string CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)NCC(=O)N4CCCC4C(=O)O)N, providing unambiguous identifiers for cross-referencing in analytical databases and cheminformatics workflows.
Each lot of Semax is produced by chemical synthesis and presents as a white to off-white lyophilized powder. Purity is not less than 98% as determined by HPLC, with identity, purity, mass confirmation and residual profile documented on the lot-specific Certificate of Analysis available on request. The methionine thioether and histidine imidazole are known handles that formulators typically consider when planning solvent compatibility, buffer selection, and long-term storage studies of research peptides of this class.
Published scientific literature has examined Semax in preclinical and in-vitro research contexts, and the identifiers above allow investigators to align in-house analytical data with peer-reviewed reports. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance. This material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion.
Physical format
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. A research reference material - not a finished product and not a delivery device. Net contents per unit are shown in the product options.
Certificate of Analysis
| Issuing laboratory | Analiza Białek |
|---|---|
| Analyte | Semax |
| CAS Number | 80714-61-0 |
| Lot / Batch | K12PP |
| Appearance | White to off-white lyophilized powder |
| Purity (HPLC) | 99% |
| Identity | Confirmed by HPLC and mass spectrometry |
Lot-specific COA available — contact [email protected] with your lot number.
Storage & handling
Store the sealed lyophilized powder at -20 C, protected from light and moisture. After reconstitution for laboratory use, keep cold and use promptly. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.
Scientific references
The following are independent, peer-reviewed publications provided for reference. They describe third-party research and are not representations by POWER BIOTECH LLC regarding this product.
- Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus — https://pubmed.ncbi.nlm.nih.gov/18537808/
- Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats — https://pubmed.ncbi.nlm.nih.gov/21520481/
- Heptapeptide Semax Effects on Expression of Genes Related to Neurotransmitter Systems — https://pmc.ncbi.nlm.nih.gov/articles/PMC5650345/
- Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats — https://pubmed.ncbi.nlm.nih.gov/17117973/
- The nootropic and analgesic effects of Semax following different routes of administration — https://pubmed.ncbi.nlm.nih.gov/9333452/
- Semax, an analog of ACTH(4-7), regulates expression of immune response genes in ischemic rat brain — https://pmc.ncbi.nlm.nih.gov/articles/PMC4133108/
Eligibility & terms of sale
This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.
FAQ
What is the purity and how is it verified?
Not less than 98% by HPLC; see the Certificate of Analysis for the lot-specific result.
What form does it ship in?
A lyophilized powder in a sealed vial.
Can you advise on dosing, reconstitution, or administration?
No. We provide batch documentation, storage, and handling information only; we do not provide dosing, reconstitution, administration, or therapeutic guidance.
Is lot-specific documentation available?
Yes - contact [email protected] with your lot number for the Certificate of Analysis.
Related reference materials
Sold by POWER BIOTECH LLC, Casper, WY 82609, United States · [email protected]. FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.
