KPV

$77.99

Lyophilized powder - research reference material

This material is supplied solely as a laboratory research article. Buyer is responsible for ensuring lawful purchase, handling, storage, and use. We do not provide administration or therapeutic guidance.

Quality Certificates

Independent third-party lab analysis (CoA) - from our own in-house brand.

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KPV - Melanocortin-Derived Tripeptide, Research Reference Material

FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.

2D chemical structure of KPV - Melanocortin-Derived Tripeptide, Research Reference Material
Two-dimensional chemical structure. Depiction for identification only.
Amino-acid sequence of KPV - Melanocortin-Derived Tripeptide, Research Reference Material
Primary amino-acid sequence, N to C. Tiles colored by side-chain class.

Analytical Identity

Identity & nomenclature
Common nameKPV
Amino-acid sequenceKPV
Sequence (3-letter)Lys-Pro-Val
Residues3
CAS Number67727-97-3
PubChem CID125672
InChIKeyYSPZCHGIWAQVKQ-AVGNSLFASA-N
SMILESCC(C)C(C(=O)O)NC(=O)C1CCCN1C(=O)C(CCCCN)N
Physicochemical
Molecular formulaC16H30N4O4
Molecular weight342.43 g/mol
Monoisotopic mass342.2267 Da
AppearanceWhite to off-white lyophilized powder
Physical formLyophilized powder
Quality & provenance
PurityNot less than 98% by HPLC (see lot-specific Certificate of Analysis)
SourceSynthetic
Catalog / SKUKPV

KPV is supplied as a laboratory research reference material intended strictly for in-vitro and laboratory research use only. This synthetic tripeptide corresponds to the C-terminal fragment of the alpha-melanocyte-related melanocortin sequence, comprising L-lysine, L-proline, and L-valine in the linear order Lys-Pro-Val (three residues, N-terminal free amine on lysine, C-terminal free carboxylate on valine). The compound is catalogued under CAS 67727-97-3 and PubChem CID 125672, with the InChIKey YSPZCHGIWAQVKQ-AVGNSLFASA-N and the isomeric SMILES CC(C)C(C(=O)O)NC(=O)C1CCCN1C(=O)C(CCCCN)N providing unambiguous structural descriptors for cheminformatics workflows and database cross-referencing.

The molecular formula C16H30N4O4 corresponds to an average molecular weight of 342.43 g/mol and a monoisotopic mass of 342.2267 Da, values useful for calibrating LC-MS and high-resolution mass spectrometry methods when KPV is used as an analytical standard. The central proline residue introduces a conformational constraint through its cyclic secondary amine, while the lysine side chain contributes a primary epsilon-amino group (a basic, protonatable site relevant to ion-exchange behavior and reversed-phase retention) and valine supplies a hydrophobic beta-branched terminus. This combination gives KPV a distinctive chromatographic and mass-spectral fingerprint suitable for identity confirmation, method development, and reference peak assignment.

Physically, KPV is provided as a white to off-white lyophilized powder of synthetic origin, with purity established at not less than 98% by HPLC and documented on a lot-specific Certificate of Analysis available on request. The lyophilized format supports accurate gravimetric handling in analytical laboratories and long-term stability under appropriate cold, desiccated storage conditions typical for short peptide reference materials.

Published scientific literature has examined KPV in preclinical, in-vitro, and biochemical research contexts, and it is frequently cited as a melanocortin-derived tripeptide of interest in structural and mechanistic studies. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance. This KPV research reference material is not a drug, supplement, cosmetic, or food, and is not intended for human or veterinary use, injection, or ingestion. It is offered solely to qualified researchers and institutional laboratories for characterization, analytical, and in-vitro reference applications.

Physical format

Supplied as a lyophilized (freeze-dried) powder in a sealed vial. A research reference material - not a finished product and not a delivery device. Net contents per unit are shown in the product options.

Certificate of Analysis

Issuing laboratoryAnaliza Białek
AnalyteKPV
CAS Number67727-97-3
Lot / BatchK12PP
AppearanceWhite to off-white lyophilized powder
Purity (HPLC)99%
IdentityConfirmed by HPLC and mass spectrometry

Lot-specific COA available — contact [email protected] with your lot number.

Storage & handling

Store the sealed lyophilized powder at -20 C, protected from light and moisture. After reconstitution for laboratory use, keep cold and use promptly. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.

Scientific references

The following are independent, peer-reviewed publications provided for reference. They describe third-party research and are not representations by POWER BIOTECH LLC regarding this product.

  1. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases — https://pubmed.ncbi.nlm.nih.gov/14500533/
  2. The tripeptide KdPT is hydrolytically stable and reduces TNF-α-induced pro-inflammatory mediators in human keratinocytes — https://pmc.ncbi.nlm.nih.gov/articles/PMC2659694/
  3. Targeted delivery of the tripeptide KPV via a nanoparticle drug delivery system attenuates colitis in mice — https://pubmed.ncbi.nlm.nih.gov/23022960/
  4. Anti-inflammatory effect of the tripeptide KPV in cells and animal models of inflammatory bowel disease — https://pmc.ncbi.nlm.nih.gov/articles/PMC4669962/
  5. The anti-inflammatory tripeptide KPV inhibits NF-kB nuclear translocation, ICAM-1 expression and neutrophil recruitment — https://pubmed.ncbi.nlm.nih.gov/12626594/
  6. Alpha-MSH and its tripeptide KPV downregulate pro-inflammatory cytokine production in keratinocytes — https://pmc.ncbi.nlm.nih.gov/articles/PMC3057437/

Eligibility & terms of sale

This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.

FAQ

What is the purity and how is it verified?
Not less than 98% by HPLC; see the Certificate of Analysis for the lot-specific result.

What form does it ship in?
A lyophilized powder in a sealed vial.

Can you advise on dosing, reconstitution, or administration?
No. We provide batch documentation, storage, and handling information only; we do not provide dosing, reconstitution, administration, or therapeutic guidance.

Is lot-specific documentation available?
Yes - contact [email protected] with your lot number for the Certificate of Analysis.

Related reference materials

Sold by POWER BIOTECH LLC, Casper, WY 82609, United States · [email protected]. FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.