PE-22-28
$87.99
This material is supplied solely as a laboratory research article. Buyer is responsible for ensuring lawful purchase, handling, storage, and use. We do not provide administration or therapeutic guidance.
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Analytical Identity
| Common name | PE-22-28 |
|---|---|
| Amino-acid sequence | KQAGSSS |
| Sequence (3-letter) | Lys-Gln-Ala-Gly-Ser-Ser-Ser |
| Residues | 7 |
| CAS Number | 252977-78-1 |
| Molecular formula | C37H56N10O11 |
|---|---|
| Molecular weight | 824.9 g/mol |
| Appearance | White to off-white lyophilized powder |
| Physical form | Lyophilized powder |
| Purity | Not less than 98% by HPLC (see lot-specific Certificate of Analysis) |
|---|---|
| Source | Synthetic |
| Catalog / SKU | PE-22-28 |
PE-22-28 is supplied as a laboratory research reference material intended strictly for in-vitro and laboratory research use only. This synthetic heptapeptide corresponds to a seven-residue fragment derived from the spadin sequence and is offered as a lyophilized white to off-white powder produced by solid-phase peptide synthesis. Each lot is presented as a single-component reference item, catalog code PE-22-28, sourced synthetically rather than from any biological extract.
The identity of PE-22-28 is defined by CAS Number 252977-78-1, molecular formula C37H56N10O11, and a monoisotopic-consistent average molecular weight of 824.9 g/mol. The primary structure is the linear heptapeptide KQAGSSS in one-letter code, or Lys-Gln-Ala-Gly-Ser-Ser-Ser in three-letter notation, comprising seven residues with free N- and C-termini as supplied. The sequence combines a basic N-terminal lysine, a polar glutamine, a small hydrophobic alanine, a conformationally flexible glycine hinge, and a C-terminal triserine motif, giving the molecule multiple hydroxyl and amide side-chain functionalities that dominate its hydrogen-bonding and solubility behavior in aqueous buffers typical of analytical workflows.
Purity is specified as not less than 98% by reverse-phase HPLC, with identity and lot-specific analytical values, including mass-spectrometric confirmation of molecular weight, water and counter-ion content where applicable, and chromatographic profile, documented on the Certificate of Analysis released with each batch and available on request. These parameters make PE-22-28 suitable as a characterization standard, chromatographic reference, or comparator material in method development, stability studies, peptide mapping, and other bench-scale analytical investigations.
Published scientific literature has examined PE-22-28 in preclinical, in-vitro contexts, and this listing is provided solely to support such laboratory reference work. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance of any kind. PE-22-28 is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion.
Physical format
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. A research reference material - not a finished product and not a delivery device. Net contents per unit are shown in the product options.
Certificate of Analysis
| Analyte | PE-22-28 |
|---|---|
| CAS Number | 252977-78-1 |
| Appearance | White to off-white lyophilized powder |
| Identity | Confirmed by HPLC and mass spectrometry |
Lot-specific COA available — contact [email protected] with your lot number.
Storage & handling
Store the sealed lyophilized powder at -20 C, protected from light and moisture. After reconstitution for laboratory use, keep cold and use promptly. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.
Scientific references
The following are independent, peer-reviewed publications provided for reference. They describe third-party research and are not representations by POWER BIOTECH LLC regarding this product.
- Spadin, a sortilin-derived peptide, targeting rapid-acting antidepressant — https://pubmed.ncbi.nlm.nih.gov/20440275/
- Antidepressant-like effects of PE-22-28, a TREK-1 channel blocker — https://pmc.ncbi.nlm.nih.gov/articles/PMC4259505/
- Identification of a novel antidepressant peptide based on the structure of spadin — https://pubmed.ncbi.nlm.nih.gov/24412211/
- Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype — https://pmc.ncbi.nlm.nih.gov/articles/PMC3198027/
- Spadin as a new antidepressant: absence of TREK-1-related side effects — https://pubmed.ncbi.nlm.nih.gov/31269437/
Eligibility & terms of sale
This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.
FAQ
What is the purity and how is it verified?
Not less than 98% by HPLC; see the Certificate of Analysis for the lot-specific result.
What form does it ship in?
A lyophilized powder in a sealed vial.
Can you advise on dosing, reconstitution, or administration?
No. We provide batch documentation, storage, and handling information only; we do not provide dosing, reconstitution, administration, or therapeutic guidance.
Is lot-specific documentation available?
Yes - contact [email protected] with your lot number for the Certificate of Analysis.
Related reference materials
Sold by POWER BIOTECH LLC, Casper, WY 82609, United States · [email protected]. FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.
