Humanin

$134.99

Lyophilized powder - research reference material

This material is supplied solely as a laboratory research article. Buyer is responsible for ensuring lawful purchase, handling, storage, and use. We do not provide administration or therapeutic guidance.

Humanin - Mitochondrial-Derived 24-mer Peptide, Research Reference Material

FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.

Amino-acid sequence of Humanin - Mitochondrial-Derived 24-mer Peptide, Research Reference Material
Primary amino-acid sequence, N to C. Tiles colored by side-chain class.

Analytical Identity

Identity & nomenclature
Common nameHumanin
Amino-acid sequenceMAPRGFSCLLLLTSEIDLPVKRRA
Sequence (3-letter)Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Residues24
CAS Number330936-69-1
Physicochemical
Molecular formulaC112H184N28O30S2
Molecular weight2438.0 g/mol
AppearanceWhite to off-white lyophilized powder
Physical formLyophilized powder
Quality & provenance
PurityNot less than 98% by HPLC (see lot-specific Certificate of Analysis)
SourceSynthetic
Catalog / SKUHUMANIN

Humanin is offered as a laboratory research reference material intended for in-vitro and laboratory research use only. This synthetic 24-residue peptide corresponds to the sequence Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala (one-letter: MAPRGFSCLLLLTSEIDLPVKRRA), catalogued under CAS 330936-69-1 and SKU HUMANIN for straightforward inventory tracking in analytical workflows.

The molecular formula C112H184N28O30S2 corresponds to a monoisotopic-compatible average molecular weight of 2438.0 g/mol, reflecting a hydrophobic core dominated by a Leu-Leu-Leu-Leu tetrad and flanking aliphatic residues (Ile, Val, Ala), a single sulfur-bearing cysteine at position 8, an N-terminal methionine, and a basic C-terminal cluster (Lys-Arg-Arg) that contributes to the peptide's net charge profile at physiological pH ranges relevant to buffer selection. The lone Cys residue is a point of analytical attention for investigators developing HPLC or LC-MS methods, since free thiol chemistry can influence chromatographic retention, disulfide-mediated dimerization, and oxidation state during handling.

Humanin is produced by solid-phase peptide synthesis and supplied as a white to off-white lyophilized powder with purity not less than 98% by HPLC, as documented on the lot-specific Certificate of Analysis. The CoA typically reports reverse-phase HPLC purity, mass confirmation consistent with 2438.0 g/mol, sequence verification, and appearance, giving analytical chemists and formulation scientists a defensible identity and purity record for method development, reference standard preparation, assay calibration, and comparative characterization studies.

Published scientific literature has examined Humanin in preclinical research contexts, and the peptide is frequently cited as a mitochondrial-derived 24-mer of interest in biochemistry and molecular biology reference collections. PEPTIDE.Power makes no therapeutic, diagnostic, or efficacy claims regarding this material and provides no administration or dosing guidance; its listing here is strictly as a characterized chemical reference item.

This material is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. It is sold exclusively for in-vitro laboratory research, analytical reference, and method-development purposes by qualified professionals. Identity and purity are documented on the lot-specific Certificate of Analysis, available on request.

Physical format

Supplied as a lyophilized (freeze-dried) powder in a sealed vial. A research reference material - not a finished product and not a delivery device. Net contents per unit are shown in the product options.

Certificate of Analysis

AnalyteHumanin
CAS Number330936-69-1
AppearanceWhite to off-white lyophilized powder
IdentityConfirmed by HPLC and mass spectrometry

Lot-specific COA available — contact [email protected] with your lot number.

Storage & handling

Store the sealed lyophilized powder at -20 C, protected from light and moisture. After reconstitution for laboratory use, keep cold and use promptly. Handle per standard laboratory practice; a Safety Data Sheet (SDS) is available on request.

Scientific references

The following are independent, peer-reviewed publications provided for reference. They describe third-party research and are not representations by POWER BIOTECH LLC regarding this product.

  1. Humanin: a harbinger of mitochondrial-derived peptides? — https://pmc.ncbi.nlm.nih.gov/articles/PMC3955092/
  2. Humanin peptide suppresses apoptosis by interfering with Bax activation — https://pubmed.ncbi.nlm.nih.gov/12642658/
  3. Humanin: a novel central regulator of peripheral insulin action — https://pmc.ncbi.nlm.nih.gov/articles/PMC2880228/
  4. Humanin protects against Alzheimer's disease-relevant insults in vitro and in vivo — https://pubmed.ncbi.nlm.nih.gov/19386761/
  5. The mitochondrial-derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction — https://pmc.ncbi.nlm.nih.gov/articles/PMC4509431/
  6. Naturally occurring variation in the mitochondrial-derived peptide MOTS-c and the risk of type 2 diabetes — https://pmc.ncbi.nlm.nih.gov/articles/PMC5478071/

Eligibility & terms of sale

This material is sold to qualified laboratory and research buyers for lawful research use only. It is not a drug, supplement, cosmetic, or food, and is not for human or veterinary use, injection, or ingestion. By purchasing, you confirm you are 21 or older and will use this material only for lawful laboratory research.

FAQ

What is the purity and how is it verified?
Not less than 98% by HPLC; see the Certificate of Analysis for the lot-specific result.

What form does it ship in?
A lyophilized powder in a sealed vial.

Can you advise on dosing, reconstitution, or administration?
No. We provide batch documentation, storage, and handling information only; we do not provide dosing, reconstitution, administration, or therapeutic guidance.

Is lot-specific documentation available?
Yes - contact [email protected] with your lot number for the Certificate of Analysis.

Related reference materials

Sold by POWER BIOTECH LLC, Casper, WY 82609, United States · [email protected]. FOR LABORATORY RESEARCH USE ONLY. Not a drug, supplement, cosmetic, or food. Not for human or veterinary use, ingestion, injection, or any in-vivo administration. Not evaluated by the FDA.